Stability-indicating HPLC method for simultaneous determination of montelukast and fexofenadine hydrochloride
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Stability-indicating HPLC Method for Simultaneous Determination of Montelukast and Fexofenadine Hydrochloride
A simple, specific, accurate, and stability-indicating reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of montelukast and fexofenadine hydrochloride, using a Lichrospher(®) 100, RP-18e column and a mobile phase composed of methanol:0.1% o-phosphoric acid (90:10 v/v), pH 6.8. The retention times of montelukast and fexofenadine hydroc...
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A new stability-indicating RP-HPLC method was developed for the simultaneous determination of fexofenadine hydrochloride and montelukast in combined dosage form, using a Aligent, Zorbax (Make: 150 mmx4.6 mm I.D; particle size 5μm and a mobile phase composed of phospahte buffer (pH 4.0): Acetonitile (60:40 v/v) at a flow rate of 1.0mL/min. The retention times of fexofenadine hydrochloride and mo...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2013
ISSN: 0250-474X
DOI: 10.4103/0250-474x.117426